Spermidine trihydrochloride is the hydrochloride salt form of spermidine, a naturally occurring polyamine found in living organisms. It plays an essential role in cellular physiological processes and has been extensively studied for its involvement in cellular homeostasis and autophagy-related pathways. Compared to free-base spermidine, the trihydrochloride form offers enhanced chemical stability, improved handling characteristics, and greater suitability for industrial-scale formulation, making it an ideal raw material for dietary supplements, functional foods, and research applications.

Product Description

Appearance: White to off-white crystalline powder
Solubility: Freely soluble in water
CAS Number: 334-50-9
Molecular Weight: 254.63
Molecular Formula: C₇H₂₂N₃Cl₃

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Product Specifications

Product Process and Advantages

· High-Purity Refining Process: Achieves overall purity ≥99% through multi-stage recrystallization, with impurity levels significantly below industry standards.
· Superior Appearance & Clean-Label Properties: Pure white powder with no noticeable odor; produced via green synthesis, non-GMO, allergen-free, and gluten-free, meeting global clean-label and compliance requirements.
· Outstanding Stability: The HCl salt form provides greater chemical stability and antioxidant capacity compared to free base, ideal for dietary supplement formulation development and long-term storage.
· Compliance-Ready Manufacturing: In-house facilities strictly follow cGMP standards and are certified by ISO 9001:2015, HALAL, KOSHER, and other international authorities, ensuring full regulatory compliance worldwide.

· Supply Chain Excellence: Vertically integrated from R&D to production, supported by strategic U.S.-based warehousing, enabling reliable bulk supply and rapid delivery.

Product Functions and Mechanisms

· Autophagy Inducer: Spermidine is one of the most potent natural inducers of autophagy known to date. It activates cellular self-cleaning mechanisms to remove damaged mitochondria and proteins, thereby maintaining cellular homeostasis.
· Cardiovascular Protection: Helps improve vascular elasticity, supports heart health, and reduces age-related cardiovascular stress.
· Neural & Cognitive Support: Protects against neuronal damage and helps maintain cognitive sharpness and memory during aging.
· Anti-Aging Synergy: Works synergistically with NAD+ and NMN to comprehensively optimize metabolic and longevity pathways in the body.

Evidence from Research

A long-term prospective cohort study published in 2018 investigated the potential association between dietary spermidine intake and all-cause mortality. The study followed 829 participants aged 45 to 84 over a period of 20 years, analyzing their habitual dietary spermidine intake and mortality outcomes.
Participants were categorized into three groups based on daily spermidine intake: low intake (< 62.2 μmol/day), moderate intake (62.2–79.8 μmol/day), and high intake (> 79.8 μmol/day). During the follow-up, a total of 341 deaths were recorded, including 137 cardiovascular-related deaths, 94 cancer-related deaths, and 110 deaths from other causes.

The crude mortality rates observed across the low-, moderate-, and high-intake groups were 40.5%, 23.7%, and 15.1%, respectively. These findings indicate a significant inverse association between dietary spermidine intake and all-cause mortality.

The mortality risk difference between individuals with the highest and lowest spermidine intake mirrors the survival advantage associated with being 5.7 years younger, providing evidence that long-term spermidine consumption contributes to longevity.

*Data source: Kiechl, S., Pechlaner, R., Willeit, P., et al. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American Journal of Clinical Nutrition, 108(2), 371–380. https://doi.org/10.1093/ajcn/nqy102

Applications

· Dietary Supplements: As a core active ingredient in premium anti-aging capsules, fatigue-reducing powders, and comprehensive longevity formulations.
· Functional Foods & Beverages: Incorporated into health drinks, functional gummies, and energy bars designed to enhance cellular vitality.
· Cellular Nutrition & Healthy Aging Formulations: Specialized products targeting aging-related health needs, formulated for cellular repair and mitochondrial support.

· Scientific Research & Development: A key biochemical reagent used in life sciences to study apoptosis, circadian rhythms, and longevity mechanisms

Packaging & Storage

Packaging:1 kg/aluminum foil bag, or customizable upon request

Storage Conditions: Keep tightly sealed and protected from light. For long-term storage, recommended temperature is 2–8°C in a cool, dry place.
Shelf Life: 24 months.