DHMSober™

Premium Dihydromyricetin

DHMSober™ is a proprietary brand of Dihydromyricetin (DHM) developed by Shanghai Aidu Biotechnology Co., Ltd. This ingredient is derived from the widely distributed Vine Tea plant (Ampelopsis grossedentata) in Asia and belongs to naturally occurring flavonoid compounds.

Dihydromyricetin (DHM) is a class of polyphenolic compounds with well-defined botanical origins, primarily extracted from Vine Tea (Ampelopsis grossedentata) and also detectable in specific plants such as Hovenia dulcis. As one of the traditional botanical ingredients, DHM has a long history of folk application. In recent years, modern research has begun to systematically explore DHM at molecular and metabolic levels, focusing on its potential roles in alcohol metabolism pathways, oxidative stress regulation, and hepatic metabolic homeostasis, providing scientific references for its application in nutritional and functional formulations.

Product Description

Appearance: Light yellow to off-white fine powder

CAS No.: 27200-12-0
Molecular Weight: 320.25
Molecular Formula: C₁₅H₁₂O₈
Solubility: Freely soluble in hot water and hot ethanol, slightly soluble in cold water
Source: Asian Vine Tea (Ampelopsis grossedentata)
Used Part: Stem and Leaf
Available Specifications: 50%, 98%

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Product Specifications

Test Items	Specifications	Test Method
Assay	98.0% Min	HPLC
Identification	Passes all criteria tests	TLC
Loss on drying	3.0% Max	USP
Ash	0.2% Max	USP
Sieve analysis	80 Mesh	USP
Pb	0.5ppm Max	ICP-MS
As	1.0ppm Max	ICP-MS
Hg	0.1ppm Max	ICP-MS
Cd	0.5ppm Max	ICP-MS
Microbiology Control
Total Plate Count	1000cfu/g Max	USP
Yeast&Mold	100cfu/g Max	USP

(*The purity of technical indicators in the table is 98%)

Product Process and Advantages

· Structure and Bioavailability Characteristics: Dihydromyricetin (DHM) is a naturally occurring flavonoid compound with multiple phenolic hydroxyl groups, demonstrating favorable stability in metabolic studies. Its molecular structure enables participation in various physiological pathways related to oxidative stress and metabolic regulation, making it suitable for applications supporting alcohol metabolism, liver nutrition, and functional formulation development.

· High-Purity Extraction and Refining Process: AIDU Biotech employs standardized plant extraction and multi-step refining processes to obtain high-purity DHM from premium botanical sources. Through controlled extraction, purification, and refinement procedures, key quality parameters are rigorously managed to ensure product purity ≥98% and controlled impurity levels, meeting the consistency and safety requirements for dietary supplements and functional ingredients.
· Quality System and Compliant Production: All DHM raw materials are manufactured at AIDU Biotech's own production facilities under strict cGMP quality management standards. The products comply with quality criteria such as Non-GMO, Solvent-free, and Gluten-free. Each batch undergoes comprehensive physicochemical testing before release and is verified by international third-party laboratories like Eurofins, providing strong support for compliance in major global health markets including the U.S. and EU.
· Stable Supply and Delivery Capability: Leveraging a mature domestic raw material production system combined with local warehousing and logistics resources in the U.S., AIDU Biotech offers global customers stable supply, inventory support, and efficient delivery services for DHM raw materials, meeting the demands of large-scale production and long-term project collaborations.

Product Functions and Mechanisms

· Rapid Hangover Relief: Dihydromyricetin (DHM) significantly enhances the liver's ability to metabolize alcohol. By boosting the activity of Alcohol Dehydrogenase (ADH) and Acetaldehyde Dehydrogenase (ALDH) in the liver, it accelerates the breakdown of the toxic metabolite "acetaldehyde," effectively reducing post-drinking fatigue and headaches.

· Liver Protection & Lipid Balance: DHM is widely used in liver nutritional support. Studies show that it protects hepatocytes from alcohol-induced damage and maintains healthy cellular homeostasis by regulating lipid metabolism.
· Enhanced Antioxidant Capacity: As a potent natural flavonoid, DHM provides deep metabolic support. It actively participates in free radical-scavenging pathways, significantly reducing oxidative stress damage in the body.
· Improved Physical Performance & High-Altitude Adaptation: Scientific research confirms that DHM aids in post-exercise recovery and enhances the body’s adaptation to simulated high-altitude hypoxic environments, providing a scientific foundation for physical performance support products.

Scientific Research & Data Backing

DHMSober™ by AIDU Biotech is not only a natural solution for alcohol detoxification but also a precise regulator of cellular energy metabolism and liver protection.

1 Cellular Metabolic Regulation & Energy Pathway Support (AMPK / Sirtuins Signaling Pathways):

Studies have shown that in alcohol-loaded animal models, DHM participates in regulating AMPK and Sirt-1-related signaling pathways, influencing the expression levels of downstream PGC-1α. This mechanism is closely associated with mitochondrial function maintenance and cellular energy metabolic homeostasis.

·Zhang, Y., et al. (2014). Dihydromyricetin Improves Physical Performance under Simulated High Altitude. Medicine & Science in Sports & Exercise.

Applications

· Dietary Supplements: As a core functional ingredient, it is applied in dietary supplement formulations for alcohol detoxification (alcohol metabolism support), long-term liver protection, and daily metabolic balance.

· Functional Foods & Beverages: Suitable for developing "anti-hangover drinks" or "liver-protecting beverages" targeting social scenarios, supporting product designs that enhance metabolic vitality and reduce post-drinking discomfort.
· Sports Nutrition & Performance Recovery: Used in formulation systems aimed at post-exercise fatigue recovery and high-altitude adaptation, meeting the demand for physical performance support ingredients in the sports industry and among high-intensity work populations.
· Scientific Research & Product Development: As an efficient natural flavonoid derivative raw material, it is applied in basic pharmacological research, mitochondrial metabolic pathway exploration, and functional validation stages of health product development.

Packaging & Storage

Packaging Specification: Standard is 25kg/drum, with double inner plastic bags, or customized according to customer requirements.

Storage Conditions: Sealed storage, protected from moisture and light.
Shelf Life: 36 months.